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Dose expansion cohorts in Phase I trials
A rapidly increasing number of Phase I dose-finding studies, and in particular those based on the standard 3+3 design, are being prolonged with the inclusion of dose expansion cohorts (DEC) in order to better characterize the toxicity profiles of experimental agents and to study disease-specific coh...
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| 出版年: | Stat Biopharm Res |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4976787/ https://ncbi.nlm.nih.gov/pubmed/27516848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19466315.2015.1135185 |
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