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Dose expansion cohorts in Phase I trials

A rapidly increasing number of Phase I dose-finding studies, and in particular those based on the standard 3+3 design, are being prolonged with the inclusion of dose expansion cohorts (DEC) in order to better characterize the toxicity profiles of experimental agents and to study disease-specific coh...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Stat Biopharm Res
Main Authors: Iasonos, Alexia, O'Quigley, John
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976787/
https://ncbi.nlm.nih.gov/pubmed/27516848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19466315.2015.1135185
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