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Sequential Monitoring of Phase I Dose expansion cohorts

A relatively recent development in the design of Phase I dose finding studies is the inclusion of expansion cohort(s), that is the inclusion of several more patients at a level considered to be the maximum tolerated dose (MTD) established at the conclusion of the “pure” Phase I part. Little attentio...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Stat Med
Prif Awduron: Iasonos, Alexia, O'Quigley, John
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976081/
https://ncbi.nlm.nih.gov/pubmed/26854196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6894
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