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Sequential Monitoring of Phase I Dose expansion cohorts
A relatively recent development in the design of Phase I dose finding studies is the inclusion of expansion cohort(s), that is the inclusion of several more patients at a level considered to be the maximum tolerated dose (MTD) established at the conclusion of the “pure” Phase I part. Little attentio...
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| Publicado no: | Stat Med |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4976081/ https://ncbi.nlm.nih.gov/pubmed/26854196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6894 |
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