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Sequential Monitoring of Phase I Dose expansion cohorts

A relatively recent development in the design of Phase I dose finding studies is the inclusion of expansion cohort(s), that is the inclusion of several more patients at a level considered to be the maximum tolerated dose (MTD) established at the conclusion of the “pure” Phase I part. Little attentio...

詳細記述

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書誌詳細
出版年:Stat Med
主要な著者: Iasonos, Alexia, O'Quigley, John
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976081/
https://ncbi.nlm.nih.gov/pubmed/26854196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6894
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