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Early phase clinical trials—are dose expansion cohorts needed?
Dose-expansion cohorts (DECs) enable investigators to identify potentially effective drugs, for specific patient populations, in a single trial by assessing antitumour activity as early as possible. We discuss how the objectives, design and interpretation of DEC have evolved, and how DECs are changi...
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| Publicado no: | Nat Rev Clin Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4758199/ https://ncbi.nlm.nih.gov/pubmed/26441082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrclinonc.2015.174 |
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