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Adaptive Dose-Finding Studies: A Review of Model-Guided Phase I Clinical Trials
PURPOSE: We provide a comprehensive review of adaptive phase I clinical trials in oncology that used a statistical model to guide dose escalation to identify the maximum-tolerated dose (MTD). We describe the clinical setting, practical implications, and safety of such applications, with the aim of u...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society of Clinical Oncology
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4121508/ https://ncbi.nlm.nih.gov/pubmed/24982451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2013.54.6051 |
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