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Incorporating lower grade toxicity information into dose finding designs
BACKGROUND: Toxicity grades underlie the definition of a dose limiting toxicity (DLT) but in the majority of phase I designs, the information contained in the individual grades is not used. Some authors have argued that it may be more appropriate to consider a polytomous rather than dichotomous resp...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3293181/ https://ncbi.nlm.nih.gov/pubmed/21835856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774511410732 |
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