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Clinical Trial Designs for Predictive Biomarker Validation: Theoretical Considerations and Practical Challenges
PURPOSE: Biomarkers can add substantial value to current medical practice by providing an integrated approach to prediction using the genetic makeup of the tumor and the genotype of the patient to guide patient-specific treatment selection. We discuss and evaluate various clinical trial designs for...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Clinical Oncology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2734400/ https://ncbi.nlm.nih.gov/pubmed/19597023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.22.3701 |
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