Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities

Autor Roybal, Kole T., Lim, Wendell A.
Vydáno v Annu Rev Immunol (2017)

Tentative and transient natural killer cell polarization balances the requirements for discriminatory recognition and cytolytic efficacy

Autor Sinai, Parisa, Roybal, Kole T, Wülfing, Christoph
Vydáno 2010

Synthetic Biology Approaches to Engineer T cells

Autor Wu, Chia-Yung, Rupp, Levi J., Roybal, Kole T., Lim, Wendell A.
Vydáno v Curr Opin Immunol (2015)

Differential Regulation of the Period Genes in Striatal Regions following Cocaine Exposure

Autor Falcon, Edgardo, Ozburn, Angela, Mukherjee, Shibani, Roybal, Kole, McClung, Colleen A.
Vydáno 2013

Remote control of therapeutic T cells through a small molecule-gated chimeric receptor

Autor Wu, Chia-Yung, Roybal, Kole T., Puchner, Elias M., Onuffer, James, Lim, Wendell A.
Vydáno v Science (2015)

Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network

Autor Roybal, Kole T., Mace, Emily M., Mantell, Judith M., Verkade, Paul, Orange, Jordan S., Wülfing, Christoph
Vydáno v PLoS One (2015)

IFN-α suppresses GATA3 transcription from a distal exon and promotes H3K27 tri-methylation of the CNS-1 enhancer in human Th2 cells()

Autor Huber, Jonathan P., Gonzales-van Horn, Sarah R., Roybal, Kole T., Gill, Michelle A., Farrar, J. David
Vydáno 2014

IMMU-57. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION

Autor Watchmaker, Payal, Choe, Joseph, Carrera, Diego, Downey, Kira, Shahin, Maryam, Roybal, Kole, Lim, Wendell, Okada, Hideho
Vydáno v Neuro Oncol (2018)

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

Autor Morsut, Leonardo, Roybal, Kole T., Xiong, Xin, Gordley, Russell M., Coyle, Scott M., Thomson, Matthew, Lim, Wendell A.
Vydáno v Cell (2016)

CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells

Autor Rupp, Levi J., Schumann, Kathrin, Roybal, Kole T., Gate, Rachel E., Ye, Chun J., Lim, Wendell A., Marson, Alexander
Vydáno v Sci Rep (2017)

IMMU-21. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION

Autor Watchmaker, Payal, Choe, Joseph, Carrera, Diego, Gilbert, Ryan, Yu, Wei, Downey, Kira, Roybal, Kole, Lim, Wendell, Okada, Hideho
Vydáno v Neuro Oncol (2019)

Spatiotemporal Patterning During T Cell Activation Is Highly Diverse

Autor Singleton, Kentner L., Roybal, Kole T., Sun, Yi, Fu, Guo, Gascoigne, Nicholas R. J., van Oers, Nicolai S. C., Wülfing, Christoph
Vydáno 2009

Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling

Autor Roybal, Kole T., Mace, Emily M., Clark, Danielle J., Leard, Alan D., Herman, Andrew, Verkade, Paul, Orange, Jordan S., Wülfing, Christoph
Vydáno v PLoS One (2015)

Precision Tumor Recognition by T Cells With Combinatorial Antigen Sensing Circuits

Autor Roybal, Kole T., Rupp, Levi J., Morsut, Leonardo, Walker, Whitney J., McNally, Krista A., Park, Jason S., Lim, Wendell A.
Vydáno v Cell (2016)

convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting

Autor Landgraf, Kyle E., Williams, Steven R., Steiger, Daniel, Gebhart, Dana, Lok, Stephen, Martin, David W., Roybal, Kole T., Kim, Kaman Chan
Vydáno v Commun Biol (2020)

Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors

Autor Furlan, Scott N, Mandraju, Rajakumar, Brewer, Travis, Roybal, Kole, Troutman, Ty Dale, Hu, Wei, Palm, Noah W, Unni, Arun, Pasare, Chandrashekhar
Vydáno 2014

Mycobacterial Shuttle Vectors Designed for High-Level Protein Expression in Infected Macrophages

Autor Eitson, Jennifer L., Medeiros, Jennifer J., Hoover, Ashley R., Srivastava, Shashikant, Roybal, Kole T., Aínsa, José A., Hansen, Eric J., Gumbo, Tawanda, van Oers, Nicolai S. C.
Vydáno 2012

Engineering T cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors

Autor Roybal, Kole T., Williams, Jasper Z., Morsut, Leonardo, Rupp, Levi J., Kolinko, Isabel, Choe, Joseph H., Walker, Whitney J., McNally, Krista A., Lim, Wendell A.
Vydáno v Cell (2016)

Computational spatiotemporal analysis identifies WAVE2 and Cofilin as joint regulators of costimulation-mediated T cell actin dynamics

Autor Roybal, Kole T., Buck, Taráz E., Ruan, Xiongtao, Cho, Baek Hwan, Clark, Danielle J., Ambler, Rachel, Tunbridge, Helen M., Zhang, Jianwei, Verkade, Paul, Wülfing, Christoph, Murphy, Robert F.
Vydáno v Sci Signal (2016)

The CD3 ζ subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR/CD3 complex at the immunological synapse

Autor DeFord-Watts, Laura M., Dougall, David S., Belkaya, Serkan, Johnson, Blake A., Eitson, Jennifer L., Roybal, Kole T., Barylko, Barbara, Albanesi, Joseph P., Wülfing, Christoph, van Oers, Nicolai S.C.
Vydáno 2011