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CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells
Immunotherapies with chimeric antigen receptor (CAR) T cells and checkpoint inhibitors (including antibodies that antagonize programmed cell death protein 1 [PD-1]) have both opened new avenues for cancer treatment, but the clinical potential of combined disruption of inhibitory checkpoints and CAR...
Tallennettuna:
Julkaisussa: | Sci Rep |
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Päätekijät: | , , , , , , |
Aineistotyyppi: | Artigo |
Kieli: | Inglês |
Julkaistu: |
Nature Publishing Group UK
2017
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Aiheet: | |
Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5428439/ https://ncbi.nlm.nih.gov/pubmed/28389661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00462-8 |
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