Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities

Por Roybal, Kole T., Lim, Wendell A.
Publicado no Annu Rev Immunol (2017)

Tentative and transient natural killer cell polarization balances the requirements for discriminatory recognition and cytolytic efficacy

Por Sinai, Parisa, Roybal, Kole T, Wülfing, Christoph
Publicado em 2010

Synthetic Biology Approaches to Engineer T cells

Por Wu, Chia-Yung, Rupp, Levi J., Roybal, Kole T., Lim, Wendell A.
Publicado no Curr Opin Immunol (2015)

Differential Regulation of the Period Genes in Striatal Regions following Cocaine Exposure

Por Falcon, Edgardo, Ozburn, Angela, Mukherjee, Shibani, Roybal, Kole, McClung, Colleen A.
Publicado em 2013

Remote control of therapeutic T cells through a small molecule-gated chimeric receptor

Por Wu, Chia-Yung, Roybal, Kole T., Puchner, Elias M., Onuffer, James, Lim, Wendell A.
Publicado no Science (2015)

Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network

Por Roybal, Kole T., Mace, Emily M., Mantell, Judith M., Verkade, Paul, Orange, Jordan S., Wülfing, Christoph
Publicado no PLoS One (2015)

IFN-α suppresses GATA3 transcription from a distal exon and promotes H3K27 tri-methylation of the CNS-1 enhancer in human Th2 cells()

Por Huber, Jonathan P., Gonzales-van Horn, Sarah R., Roybal, Kole T., Gill, Michelle A., Farrar, J. David
Publicado em 2014

IMMU-57. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION

Por Watchmaker, Payal, Choe, Joseph, Carrera, Diego, Downey, Kira, Shahin, Maryam, Roybal, Kole, Lim, Wendell, Okada, Hideho
Publicado no Neuro Oncol (2018)

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

Por Morsut, Leonardo, Roybal, Kole T., Xiong, Xin, Gordley, Russell M., Coyle, Scott M., Thomson, Matthew, Lim, Wendell A.
Publicado no Cell (2016)

CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells

Por Rupp, Levi J., Schumann, Kathrin, Roybal, Kole T., Gate, Rachel E., Ye, Chun J., Lim, Wendell A., Marson, Alexander
Publicado no Sci Rep (2017)

IMMU-21. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION

Por Watchmaker, Payal, Choe, Joseph, Carrera, Diego, Gilbert, Ryan, Yu, Wei, Downey, Kira, Roybal, Kole, Lim, Wendell, Okada, Hideho
Publicado no Neuro Oncol (2019)

Spatiotemporal Patterning During T Cell Activation Is Highly Diverse

Por Singleton, Kentner L., Roybal, Kole T., Sun, Yi, Fu, Guo, Gascoigne, Nicholas R. J., van Oers, Nicolai S. C., Wülfing, Christoph
Publicado em 2009

Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling

Por Roybal, Kole T., Mace, Emily M., Clark, Danielle J., Leard, Alan D., Herman, Andrew, Verkade, Paul, Orange, Jordan S., Wülfing, Christoph
Publicado no PLoS One (2015)

Precision Tumor Recognition by T Cells With Combinatorial Antigen Sensing Circuits

Por Roybal, Kole T., Rupp, Levi J., Morsut, Leonardo, Walker, Whitney J., McNally, Krista A., Park, Jason S., Lim, Wendell A.
Publicado no Cell (2016)

convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting

Por Landgraf, Kyle E., Williams, Steven R., Steiger, Daniel, Gebhart, Dana, Lok, Stephen, Martin, David W., Roybal, Kole T., Kim, Kaman Chan
Publicado no Commun Biol (2020)

Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors

Por Furlan, Scott N, Mandraju, Rajakumar, Brewer, Travis, Roybal, Kole, Troutman, Ty Dale, Hu, Wei, Palm, Noah W, Unni, Arun, Pasare, Chandrashekhar
Publicado em 2014

Mycobacterial Shuttle Vectors Designed for High-Level Protein Expression in Infected Macrophages

Por Eitson, Jennifer L., Medeiros, Jennifer J., Hoover, Ashley R., Srivastava, Shashikant, Roybal, Kole T., Aínsa, José A., Hansen, Eric J., Gumbo, Tawanda, van Oers, Nicolai S. C.
Publicado em 2012

Engineering T cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors

Por Roybal, Kole T., Williams, Jasper Z., Morsut, Leonardo, Rupp, Levi J., Kolinko, Isabel, Choe, Joseph H., Walker, Whitney J., McNally, Krista A., Lim, Wendell A.
Publicado no Cell (2016)

Computational spatiotemporal analysis identifies WAVE2 and Cofilin as joint regulators of costimulation-mediated T cell actin dynamics

Por Roybal, Kole T., Buck, Taráz E., Ruan, Xiongtao, Cho, Baek Hwan, Clark, Danielle J., Ambler, Rachel, Tunbridge, Helen M., Zhang, Jianwei, Verkade, Paul, Wülfing, Christoph, Murphy, Robert F.
Publicado no Sci Signal (2016)

The CD3 ζ subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR/CD3 complex at the immunological synapse

Por DeFord-Watts, Laura M., Dougall, David S., Belkaya, Serkan, Johnson, Blake A., Eitson, Jennifer L., Roybal, Kole T., Barylko, Barbara, Albanesi, Joseph P., Wülfing, Christoph, van Oers, Nicolai S.C.
Publicado em 2011