Engineering T cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors

Redirecting T cells to attack cancer using engineered chimeric receptors provides powerful new therapeutic capabilities. But the effectiveness of therapeutic T cells is constrained by the endogenous T cell response: certain facets of natural response programs can be toxic, whereas other responses, s...

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Udgivet i:Cell
Main Authors: Roybal, Kole T., Williams, Jasper Z., Morsut, Leonardo, Rupp, Levi J., Kolinko, Isabel, Choe, Joseph H., Walker, Whitney J., McNally, Krista A., Lim, Wendell A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072533/
https://ncbi.nlm.nih.gov/pubmed/27693353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.09.011
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