Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

The Notch protein is one of the most mechanistically direct transmembrane receptors – the intracellular domain contains a transcriptional regulator that is released from the membrane when engagement of the cognate extracellular ligand induces intramembrane proteolysis. We find that chimeric forms of...

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Vydáno v:Cell
Hlavní autoři: Morsut, Leonardo, Roybal, Kole T., Xiong, Xin, Gordley, Russell M., Coyle, Scott M., Thomson, Matthew, Lim, Wendell A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752866/
https://ncbi.nlm.nih.gov/pubmed/26830878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.01.012
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