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Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors
The Notch protein is one of the most mechanistically direct transmembrane receptors – the intracellular domain contains a transcriptional regulator that is released from the membrane when engagement of the cognate extracellular ligand induces intramembrane proteolysis. We find that chimeric forms of...
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| Publicado no: | Cell |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4752866/ https://ncbi.nlm.nih.gov/pubmed/26830878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.01.012 |
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