The CD3 ζ subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR/CD3 complex at the immunological synapse

T cell activation involves a cascade of TCR-mediated signals that are regulated by three distinct intracellular signaling motifs located within the cytoplasmic tails of the CD3 chains. While all the CD3 subunits possess at least one ITAM, CD3 ε subunit also contains a proline-rich sequence (PRS) and...

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Detalhes bibliográficos
Main Authors: DeFord-Watts, Laura M., Dougall, David S., Belkaya, Serkan, Johnson, Blake A., Eitson, Jennifer L., Roybal, Kole T., Barylko, Barbara, Albanesi, Joseph P., Wülfing, Christoph, van Oers, Nicolai S.C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110614/
https://ncbi.nlm.nih.gov/pubmed/21543646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002721
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