IL-1β is an innate immune sensor of microbial proteolysis

Por LaRock, Christopher N., Todd, Jordan, LaRock, Doris L., Olson, Joshua, O’Donoghue, Anthony J., Robertson, Avril A. B., Cooper, Matthew A., Hoffman, Hal M., Nizet, Victor
Publicado no Sci Immunol (2016)

Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950

Por Salla, Manohar, Butler, Mark S., Pelingon, Ruby, Kaeslin, Geraldine, Croker, Daniel E., Reid, Janet C., Baek, Jong Min, Bernhardt, Paul V., Gillam, Elizabeth M. J., Cooper, Matthew A., Robertson, Avril A. B.
Publicado no ACS Med Chem Lett (2016)

PB1-F2 Peptide Derived from Avian Influenza A Virus H7N9 Induces Inflammation via Activation of the NLRP3 Inflammasome

Por Pinar, Anita, Dowling, Jennifer K., Bitto, Natalie J., Robertson, Avril A. B., Latz, Eicke, Stewart, Cameron R., Drummond, Grant R., Cooper, Matthew A., McAuley, Julie L., Tate, Michelle D., Mansell, Ashley
Publicado no J Biol Chem (2017)

GMP Synthase Is Required for Virulence Factor Production and Infection by Cryptococcus neoformans

Por Chitty, Jessica L., Tatzenko, Tayla L., Williams, Simon J., Koh, Y. Q. Andre E., Corfield, Elizabeth C., Butler, Mark S., Robertson, Avril A. B., Cooper, Matthew A., Kappler, Ulrike, Kobe, Bostjan, Fraser, James A.
Publicado no J Biol Chem (2017)

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress

Por Dinh, Quynh Nhu, Drummond, Grant R., Kemp-Harper, Barbara K., Diep, Henry, Silva, T. Michael De, Kim, Hyun Ah, Vinh, Antony, Robertson, Avril A.B., Cooper, Matthew A., Mansell, Ashley, Chrissobolis, Sophocles, Sobey, Christopher G.
Publicado no Aging (Albany NY) (2017)

Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design

Por Chitty, Jessica L., Blake, Kirsten L., Blundell, Ross D., Koh, Y. Q. Andre E., Thompson, Merinda, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kappler, Ulrike, Williams, Simon J., Kobe, Bostjan, Fraser, James A.
Publicado no J Biol Chem (2017)

The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals

Por Tucey, Timothy M., Verma-Gaur, Jiyoti, Nguyen, Julie, Hewitt, Victoria L., Lo, Tricia L., Shingu-Vazquez, Miguel, Robertson, Avril A. B., Hill, James R., Pettolino, Filomena A., Beddoe, Travis, Cooper, Matthew A., Naderer, Thomas, Traven, Ana
Publicado no mSphere (2016)

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

Por Fuster, José J., MacLauchlan, Susan, Zuriaga, María A., Polackal, Maya N., Ostriker, Allison C., Chakraborty, Raja, Wu, Chia-Ling, Sano, Soichi, Muralidharan, Sujatha, Rius, Cristina, Vuong, Jacqueline, Jacob, Sophia, Muralidhar, Varsha, Robertson, Avril A. B., Cooper, Matthew A., Andrés, Vicente, Hirschi, Karen K., Martin, Kathleen A., Walsh, Kenneth
Publicado no Science (2017)

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

Por Neudecker, Viola, Haneklaus, Moritz, Jensen, Owen, Khailova, Ludmila, Masterson, Joanne C., Tye, Hazel, Biette, Kathryn, Jedlicka, Paul, Brodsky, Kelley S., Gerich, Mark E., Mack, Matthias, Robertson, Avril A.B., Cooper, Matthew A., Furuta, Glenn T., Dinarello, Charles A., O’Neill, Luke A., Eltzschig, Holger K., Masters, Seth L., McNamee, Eóin N.
Publicado no J Exp Med (2017)

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Por Basiorka, Ashley A., McGraw, Kathy L., Eksioglu, Erika A., Chen, Xianghong, Johnson, Joseph, Zhang, Ling, Zhang, Qing, Irvine, Brittany A., Cluzeau, Thomas, Sallman, David A., Padron, Eric, Komrokji, Rami, Sokol, Lubomir, Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Cleveland, John L., O’Neill, Luke A., Wei, Sheng, List, Alan F.
Publicado no Blood (2016)

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4(+) T cells

Por Arbore, Giuseppina, West, Erin E., Spolski, Rosanne, Robertson, Avril A. B., Klos, Andreas, Rheinheimer, Claudia, Dutow, Pavel, Woodruff, Trent M., Yu, Zu Xi, O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Köhl, Jörg, Monk, Pete, Cooper, Matthew A., Arno, Matthew, Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin D., Kemper, Claudia
Publicado no Science (2016)

A small molecule inhibitior of the NLRP3 inflammasome is a potential therapeutic for inflammatory diseases

Por Coll, Rebecca C., Robertson, Avril A. B., Chae, Jae Jin, Higgins, Sarah C., Muñoz-Planillo, Raúl, Inserra, Marco C., Vetter, Irina, Dungan, Lara S., Monks, Brian G., Stutz, Andrea, Croker, Daniel E., Butler, Mark S., Haneklaus, Moritz, Sutton, Caroline E., Núñez, Gabriel, Latz, Eicke, Kastner, Daniel L., Mills, Kingston H. G., Masters, Seth L., Schroder, Kate, Cooper, Matthew A., O’Neill, Luke A. J.
Publicado no Nat Med (2015)