MD-2 Residues Tyrosine 42, Arginine 69, Aspartic Acid 122, and Leucine 125 Provide Species Specificity for Lipid IV(A)

Por Meng, Jianmin, Drolet, Joshua R., Monks, Brian G., Golenbock, Douglas T.
Publicado em 2010

Natural Loss-of-function Mutation of Myeloid Differentiation Protein 88 Disrupts Its Ability to Form Myddosomes

Por Nagpal, Kamalpreet, Plantinga, Theo S., Sirois, Cherilyn M., Monks, Brian G., Latz, Eicke, Netea, Mihai G., Golenbock, Douglas T.
Publicado em 2011

A TIR Domain Variant of MyD88 Adapter-like (Mal)/TIRAP Results in Loss of MyD88 Binding and Reduced TLR2/TLR4 Signaling

Por Nagpal, Kamalpreet, Plantinga, Theo S., Wong, Joyce, Monks, Brian G., Gay, Nicholas J., Netea, Mihai G., Fitzgerald, Katherine A., Golenbock, Douglas T.
Publicado em 2009

Cell-type specific recognition of human Metapneumoviruses by RIG-I and TLR7 and viral interference of RIG-I ligand recognition by HMPVB1 Phosphoprotein

Por Goutagny, Nadege, Jiang, Zhaozhao, Tian, Jane, Parroche, Peggy, Schlicki, Jeanne, Monks, Brian G., Ulbrandt, Nancy, Ji, Hong, Kiener, Peter, Coyle, Anthony J., Fitzgerald, Katherine A.
Publicado em 2009

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Por Halle, Annett, Hornung, Veit, Petzold, Gabor C, Stewart, Cameron R, Monks, Brian G, Reinheckel, Thomas, Fitzgerald, Katherine A, Latz, Eicke, Moore, Kathryn J, Golenbock, Douglas T
Publicado em 2008

Molecular Genetic Analysis of an Endotoxin Nonresponder Mutant Cell Line: A Point Mutation in a Conserved Region of Md-2 Abolishes Endotoxin-Induced Signaling

Por Schromm, Andra B., Lien, Egil, Henneke, Philipp, Chow, Jesse C., Yoshimura, Atsutoshi, Heine, Holger, Latz, Eicke, Monks, Brian G., Schwartz, David A., Miyake, Kensuke, Golenbock, Douglas T.
Publicado em 2001

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

Por Rowe, Daniel C., McGettrick, Anne F., Latz, Eicke, Monks, Brian G., Gay, Nicholas J., Yamamoto, Masahiro, Akira, Shizuo, O’Neill, Luke A., Fitzgerald, Katherine A., Golenbock, Douglas T.
Publicado em 2006

Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9

Por Parroche, Peggy, Lauw, Fanny N., Goutagny, Nadege, Latz, Eicke, Monks, Brian G., Visintin, Alberto, Halmen, Kristen A., Lamphier, Marc, Olivier, Martin, Bartholomeu, Daniella C., Gazzinelli, Ricardo T., Golenbock, Douglas T.
Publicado em 2007

NF-kB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

Por Bauernfeind, Franz, Horvath, Gabor, Stutz, Andrea, Alnemri, Emad S., MacDonald, Kelly, Speert, David, Fernandes-Alnemri, Teresa, Wu, Jianghong, Monks, Brian G., Fitzgerald, Katherine A., Hornung, Veit, Latz, Eicke
Publicado em 2009

Binding of C4b-Binding Protein to Porin: A Molecular Mechanism of Serum Resistance of Neisseria gonorrhoeae

Por Ram, Sanjay, Cullinane, Meabh, Blom, Anna M., Gulati, Sunita, McQuillen, Daniel P., Monks, Brian G., O'Connell, Catherine, Boden, Ryan, Elkins, Christopher, Pangburn, Michael K., Dahlbäck, Björn, Rice, Peter A.
Publicado em 2001

Targeted Deletion of the Lipopolysaccharide (LPS)-binding Protein Gene Leads to Profound Suppression of LPS Responses Ex Vivo, whereas In Vivo Responses Remain Intact

Por Wurfel, Mark M., Monks, Brian G., Ingalls, Robin R., Dedrick, Russell L., Delude, Russell, Zhou, Dahua, Lamping, Norbert, Schumann, Ralf R., Thieringer, Rolf, Fenton, Matthew J., Wright, Samuel D., Golenbock, Douglas
Publicado em 1997

A novel factor H-Fc chimeric immunotherapeutic molecule against Neisseria gonorrhoeae

Por Shaughnessy, Jutamas, Gulati, Sunita, Agarwal, Sarika, Unemo, Magnus, Ohnishi, Makoto, Su, Xia-Hong, Monks, Brian G., Visintin, Alberto, Madico, Guillermo, Lewis, Lisa A., Golenbock, Douglas T., Reed, George W., Rice, Peter A., Ram, Sanjay
Publicado no J Immunol (2016)

The AIM2 inflammasome is essential for host-defense against cytosolic bacteria and DNA viruses

Por Rathinam, Vijay A.K., Jiang, Zhaozhao, Waggoner, Stephen N., Sharma, Shruti, Cole, Leah E., Waggoner, Lisa, Vanaja, Sivapriya Kailasan, Monks, Brian G., Ganesan, Sandhya, Latz, Eicke, Hornung, Veit, Vogel, Stefanie N., Szomolanyi-Tsuda, Eva, Fitzgerald., Katherine A.
Publicado em 2010

A small molecule inhibitior of the NLRP3 inflammasome is a potential therapeutic for inflammatory diseases

Por Coll, Rebecca C., Robertson, Avril A. B., Chae, Jae Jin, Higgins, Sarah C., Muñoz-Planillo, Raúl, Inserra, Marco C., Vetter, Irina, Dungan, Lara S., Monks, Brian G., Stutz, Andrea, Croker, Daniel E., Butler, Mark S., Haneklaus, Moritz, Sutton, Caroline E., Núñez, Gabriel, Latz, Eicke, Kastner, Daniel L., Mills, Kingston H. G., Masters, Seth L., Schroder, Kate, Cooper, Matthew A., O’Neill, Luke A. J.
Publicado no Nat Med (2015)