Natural Loss-of-function Mutation of Myeloid Differentiation Protein 88 Disrupts Its Ability to Form Myddosomes

Myeloid differentiation protein 88 (MyD88) is a key signaling adapter in Toll-like receptor (TLR) signaling. MyD88 is also one of the most polymorphic adapter proteins. We screened the reported nonsynonymous coding mutations in MyD88 to identify variants with altered function. In reporter assays, a...

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Main Authors: Nagpal, Kamalpreet, Plantinga, Theo S., Sirois, Cherilyn M., Monks, Brian G., Latz, Eicke, Netea, Mihai G., Golenbock, Douglas T.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064238/
https://ncbi.nlm.nih.gov/pubmed/21325272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.199653
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