Mutational Analysis Identifies Residues Crucial for Homodimerization of Myeloid Differentiation Factor 88 (MyD88) and for Its Function in Immune Cells

Myeloid differentiation factor 88 (MyD88) is an adaptor protein that transduces intracellular signaling pathways evoked by the Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). MyD88 is composed of an N-terminal death domain (DD) and a C-terminal Toll/IL-1 receptor (TIR) domain, separ...

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Bibliografische gegevens
Hoofdauteurs: Loiarro, Maria, Volpe, Elisabetta, Ruggiero, Vito, Gallo, Grazia, Furlan, Roberto, Maiorino, Chiara, Battistini, Luca, Sette, Claudio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2013
Onderwerpen:
Signal Transduction
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798488/
https://ncbi.nlm.nih.gov/pubmed/24019529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.490946
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