Mutational Analysis Identifies Residues Crucial for Homodimerization of Myeloid Differentiation Factor 88 (MyD88) and for Its Function in Immune Cells

Myeloid differentiation factor 88 (MyD88) is an adaptor protein that transduces intracellular signaling pathways evoked by the Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). MyD88 is composed of an N-terminal death domain (DD) and a C-terminal Toll/IL-1 receptor (TIR) domain, separ...

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Detalhes bibliográficos
Main Authors: Loiarro, Maria, Volpe, Elisabetta, Ruggiero, Vito, Gallo, Grazia, Furlan, Roberto, Maiorino, Chiara, Battistini, Luca, Sette, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798488/
https://ncbi.nlm.nih.gov/pubmed/24019529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.490946
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