The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

TRIF-related adaptor molecule (TRAM) is the fourth Toll/IL-1 resistance domain-containing adaptor to be described that participates in Toll-like receptor (TLR) signaling. TRAM functions exclusively in the TLR4 pathway. Here we show by confocal microscopy that TRAM is localized in the plasma membrane...

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Bibliographische Detailangaben
Hauptverfasser: Rowe, Daniel C., McGettrick, Anne F., Latz, Eicke, Monks, Brian G., Gay, Nicholas J., Yamamoto, Masahiro, Akira, Shizuo, O’Neill, Luke A., Fitzgerald, Katherine A., Golenbock, Douglas T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458872/
https://ncbi.nlm.nih.gov/pubmed/16603631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510041103
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