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The NALP3 inflammasome is involved in the innate immune response to amyloid-β
The fibrillar peptide amyloid-β (Aβ) has a chief function in the pathogenesis of Alzheimer’s disease. Interleukin 1β (IL-1β) is a key cytokine in the inflammatory response to Aβ. Insoluble materials such as crystals activate the inflammasome formed by the cytoplasmic receptor NALP3, which results in...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3101478/ https://ncbi.nlm.nih.gov/pubmed/18604209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1636 |
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