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Silica crystals and aluminum salts mediate NALP-3 inflammasome activation via phagosomal destabilization
Inhalation of silica crystals causes inflammation in the alveolar space. Prolonged silica exposure can lead to the development of silicosis, an irreversible, fibrotic pulmonary disease. The mechanisms by which silica and other crystals activate immune cells are not well understood. Here, we demonstr...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2834784/ https://ncbi.nlm.nih.gov/pubmed/18604214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1631 |
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