Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9

Hemozoin (HZ) is an insoluble crystal formed in the food vacuole of malaria parasites. HZ has been reported to induce inflammation by directly engaging Toll-like receptor (TLR) 9, an endosomal receptor. “Synthetic” HZ (β-hematin), typically generated from partially purified extracts of bovine hemin,...

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Библиографические подробности
Главные авторы: Parroche, Peggy, Lauw, Fanny N., Goutagny, Nadege, Latz, Eicke, Monks, Brian G., Visintin, Alberto, Halmen, Kristen A., Lamphier, Marc, Olivier, Martin, Bartholomeu, Daniella C., Gazzinelli, Ricardo T., Golenbock, Douglas T.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2007
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1794278/
https://ncbi.nlm.nih.gov/pubmed/17261807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608745104
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