Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

Malaria parasites within red blood cells digest host hemoglobin into a hydrophobic heme polymer, known as hemozoin (HZ), which is subsequently released into the blood stream and then captured by and concentrated in the reticulo-endothelial system. Accumulating evidence suggests that HZ is immunologi...

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Detalhes bibliográficos
Main Authors: Coban, Cevayir, Ishii, Ken J., Kawai, Taro, Hemmi, Hiroaki, Sato, Shintaro, Uematsu, Satoshi, Yamamoto, Masahiro, Takeuchi, Osamu, Itagaki, Sawako, Kumar, Nirbhay, Horii, Toshihiro, Akira, Shizuo
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212757/
https://ncbi.nlm.nih.gov/pubmed/15630134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20041836
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