Essential role of IPS-1 in innate immune responses against RNA viruses

IFN-β promoter stimulator (IPS)-1 was recently identified as an adapter for retinoic acid–inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (Mda5), which recognize distinct RNA viruses. Here we show the critical role of IPS-1 in antiviral responses in vivo. IPS-1–deficient mice...

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Main Authors: Kumar, Himanshu, Kawai, Taro, Kato, Hiroki, Sato, Shintaro, Takahashi, Ken, Coban, Cevayir, Yamamoto, Masahiro, Uematsu, Satoshi, Ishii, Ken J., Takeuchi, Osamu, Akira, Shizuo
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118350/
https://ncbi.nlm.nih.gov/pubmed/16785313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20060792
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