The AIM2 inflammasome is essential for host-defense against cytosolic bacteria and DNA viruses

Inflammasomes regulate the activity of capase-1 and maturation of interleukin-1β and interleukin-18. Recently, AIM2 was shown to bind DNA and engage ASC to form a caspase-1 activating inflammasome. Using Aim2-deficient mice, we reveal a central role for AIM2 in regulating caspase-1-dependent maturat...

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Detalhes bibliográficos
Main Authors: Rathinam, Vijay A.K., Jiang, Zhaozhao, Waggoner, Stephen N., Sharma, Shruti, Cole, Leah E., Waggoner, Lisa, Vanaja, Sivapriya Kailasan, Monks, Brian G., Ganesan, Sandhya, Latz, Eicke, Hornung, Veit, Vogel, Stefanie N., Szomolanyi-Tsuda, Eva, Fitzgerald., Katherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887480/
https://ncbi.nlm.nih.gov/pubmed/20351692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1864
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