Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950

[Image: see text] MCC950 is an orally bioavailable small molecule inhibitor of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome that exhibits remarkable activity in multiple models of inflammatory disease. Incubation of MCC950 with human liver microsomes, and subsequent a...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Salla, Manohar, Butler, Mark S., Pelingon, Ruby, Kaeslin, Geraldine, Croker, Daniel E., Reid, Janet C., Baek, Jong Min, Bernhardt, Paul V., Gillam, Elizabeth M. J., Cooper, Matthew A., Robertson, Avril A. B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2016
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150672/
https://ncbi.nlm.nih.gov/pubmed/27994733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00198
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