Inhibiting the NLRP3 Inflammasome With MCC950 Ameliorates Isoflurane-Induced Pyroptosis and Cognitive Impairment in Aged Mice

Nod-like receptor protein 3 (NLRP3) inflammasome activation has been implicated in the pathogenesis of general anesthesia (GA)-induced neuroinflammation and cognitive impairment in aged rodents. However, the cellular basis for cognitive impairment is still not fully understood, and effective pharmac...

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Vydáno v:Front Cell Neurosci
Hlavní autoři: Fan, Yunxia, Du, Liwu, Fu, Qun, Zhou, Zhiqiang, Zhang, Jingyu, Li, Guomin, Wu, Jing
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6262296/
https://ncbi.nlm.nih.gov/pubmed/30524241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00426
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