Translational Bioinformatics Approaches to Drug Development

par Readhead, Ben, Dudley, Joel
Publié 2013

Critical period plasticity-related transcriptional aberrations in schizophrenia and bipolar disorder

par Smith, Milo R., Readhead, Ben, Dudley, Joel T., Morishita, Hirofumi
Publié dans Schizophr Res (2018)

PI3K inhibitors protect against glucocorticoid-induced skin atrophy

par Agarwal, Shivani, Mirzoeva, Salida, Readhead, Ben, Dudley, Joel T., Budunova, Irina
Publié dans EBioMedicine (2019)

Sexual dimorphism in atrophic effects of topical glucocorticoids is driven by differential regulation of atrophogene REDD1 in male and female skin

par Baida, Gleb, Agarwal, Shivani, Readhead, Ben, Dudley, Joel T., Budunova, Irina
Publié dans Oncotarget (2020)

Integrative network modeling approaches to personalized cancer medicine

par Kidd, Brian A, Readhead, Ben P, Eden, Caroline, Parekh, Samir, Dudley, Joel T
Publié dans Per Med (2015)

Computational Approaches to Drug Repurposing and Pharmacology

par Hodos, Rachel A, Kidd, Brian A, Khader, Shameer, Readhead, Ben P, Dudley, Joel T
Publié dans Wiley Interdiscip Rev Syst Biol Med (2016)

Systematic Analysis of Environmental Chemicals That Dysregulate Critical Period Plasticity-Related Gene Expression Reveals Common Pathways That Mimic Immune Response to Pathogen

par Smith, Milo R., Yevoo, Priscilla, Sadahiro, Masato, Readhead, Ben, Kidd, Brian, Dudley, Joel T., Morishita, Hirofumi
Publié dans Neural Plast (2020)

Automated Detection of Off-Label Drug Use

par Jung, Kenneth, LePendu, Paea, Chen, William S., Iyer, Srinivasan V., Readhead, Ben, Dudley, Joel T., Shah, Nigam H.
Publié 2014

A Network-Biology Informed Computational Drug Repositioning Strategy to Target Disease Risk Trajectories and Comorbidities of Peripheral Artery Disease

par Shameer, Khader, Dow, Garrett, Glicksberg, Benjamin S., Johnson, Kipp W., Ze, Yi, Tomlinson, Max S., Readhead, Ben, Dudley, Joel T., Kullo, Iftikhar J.
Publié dans AMIA Jt Summits Transl Sci Proc (2018)

Deletion of the glucocorticoid receptor chaperone FKBP51 prevents glucocorticoid-induced skin atrophy

par Baida, Gleb, Bhalla, Pankaj, Yemelyanov, Alexander, Stechschulte, Lance A., Shou, Weinian, Readhead, Ben, Dudley, Joel T., Sánchez, Edwin R., Budunova, Irina
Publié dans Oncotarget (2018)

Enabling Precision Cardiology Through Multiscale Biology and Systems Medicine

par Johnson, Kipp W., Shameer, Khader, Glicksberg, Benjamin S., Readhead, Ben, Sengupta, Partho P., Björkegren, Johan L.M., Kovacic, Jason C., Dudley, Joel T.
Publié dans JACC Basic Transl Sci (2017)

Systems Genetic Analyses Highlight a TGFβ-FOXO3 Dependent Striatal Astrocyte Network Conserved across Species and Associated with Stress, Sleep, and Huntington’s Disease

par Scarpa, Joseph R., Jiang, Peng, Losic, Bojan, Readhead, Ben, Gao, Vance D., Dudley, Joel T., Vitaterna, Martha H., Turek, Fred W., Kasarskis, Andrew
Publié dans PLoS Genet (2016)

Genome-wide analysis indicates association between heterozygote advantage and healthy aging in humans

par Xu, Ke, Kosoy, Roman, Shameer, Khader, Kumar, Sudhir, Liu, Li, Readhead, Ben, Belbin, Gillian M., Lee, Hao-Chih, Chen, Rong, Dudley, Joel T.
Publié dans BMC Genet (2019)

REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids

par Baida, Gleb, Bhalla, Pankaj, Kirsanov, Kirill, Lesovaya, Ekaterina, Yakubovskaya, Marianna, Yuen, Kit, Guo, Shuchi, Lavker, Robert M, Readhead, Ben, Dudley, Joel T, Budunova, Irina
Publié dans EMBO Mol Med (2015)

Rapamycin Modulates Glucocorticoid Receptor Function, Blocks Atrophogene REDD1, and Protects Skin from Steroid Atrophy

par Lesovaya, Ekaterina, Agarwal, Shivani, Readhead, Ben, Vinokour, Elena, Baida, Gleb, Bhalla, Pankaj, Kirsanov, Kirill, Yakubovskaya, Marianna, Platanias, Leonidas C., Dudley, Joel T., Budunova, Irina
Publié dans J Invest Dermatol (2018)

Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits

par Zhang, Wen, Voloudakis, Georgios, Rajagopal, Veera M., Readhead, Ben, Dudley, Joel T., Schadt, Eric E., Björkegren, Johan L. M., Kim, Yungil, Fullard, John F., Hoffman, Gabriel E., Roussos, Panos
Publié dans Nat Commun (2019)

Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions

par Zakirova, Zuchra, Fanutza, Tomas, Bonet, Justine, Readhead, Ben, Zhang, Weijia, Yi, Zhengzi, Beauvais, Genevieve, Zwaka, Thomas P., Ozelius, Laurie J., Blitzer, Robert D., Gonzalez-Alegre, Pedro, Ehrlich, Michelle E.
Publié dans PLoS Genet (2018)

Systems Pharmacology Identifies an Arterial Wall Regulatory Gene Network Mediating Coronary Artery Disease Side Effects of Antiretroviral Therapy

par Frades, Itziar, Readhead, Ben, Amadori, Letizia, Koplev, Simon, Talukdar, Husain A., Crane, Heidi M., Crane, Paul K., Kovacic, Jason C., Dudley, Joel T., Giannarelli, Chiara, Björkegren, Johan LM., Peter, Inga
Publié dans Circ Genom Precis Med (2019)

Systematic analyses of drugs and disease indications in RepurposeDB reveal pharmacological, biological and epidemiological factors influencing drug repositioning

par Shameer, Khader, Glicksberg, Benjamin S, Hodos, Rachel, Johnson, Kipp W, Badgeley, Marcus A, Readhead, Ben, Tomlinson, Max S, O’Connor, Timothy, Miotto, Riccardo, Kidd, Brian A, Chen, Rong, Ma’ayan, Avi, Dudley, Joel T
Publié dans Brief Bioinform (2017)

Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathol...

par Haure-Mirande, Jean-Vianney, Wang, Minghui, Audrain, Mickael, Fanutza, Tomas, Kim, Soong Ho, Heja, Szilvia, Readhead, Ben, Dudley, Joel T., Blitzer, Robert D., Schadt, Eric E., Zhang, Bin, Gandy, Sam, Ehrlich, Michelle E.
Publié dans Mol Psychiatry (2018)