Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden

Integrative gene network approaches enable new avenues of exploration that implicate causal genes in sporadic late-onset Alzheimer’s disease (LOAD) pathogenesis, thereby offering novel insights for drug-discovery programs. We previously constructed a probabilistic causal network model of sporadic LO...

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Publicado no:Mol Psychiatry
Main Authors: Haure-Mirande, Jean-Vianney, Wang, Minghui, Audrain, Mickael, Fanutza, Tomas, Kim, Soong Ho, Heja, Szilvia, Readhead, Ben, Dudley, Joel T., Blitzer, Robert D., Schadt, Eric E., Zhang, Bin, Gandy, Sam, Ehrlich, Michelle E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494440/
https://ncbi.nlm.nih.gov/pubmed/30283032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-018-0255-6
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