Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau

TYROBP/DAP12 forms complexes with ectodomains of immune receptors (TREM2, SIRPβ1, CR3) associated with Alzheimer’s disease (AD) and is a network hub and driver in the complement subnetwork identified by multi-scale gene network studies of postmortem human AD brain. Using transgenic or viral approach...

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Publicado no:Mol Psychiatry
Main Authors: Audrain, Mickael, Haure-Mirande, Jean-Vianney, Wang, Minghui, Kim, Soong Ho, Fanutza, Tomas, Chakrabarty, Paramita, Fraser, Paul, St George-Hyslop, Peter H., Golde, Todd E., Blitzer, Robert D., Schadt, Eric E., Zhang, Bin, Ehrlich, Michelle E., Gandy, Sam
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447470/
https://ncbi.nlm.nih.gov/pubmed/30283031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-018-0258-3
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