Systems Pharmacology Identifies an Arterial Wall Regulatory Gene Network Mediating Coronary Artery Disease Side Effects of Antiretroviral Therapy

BACKGROUND: Antiretroviral therapy (ART) for HIV infection increases risk for coronary artery disease (CAD), presumably by causing dyslipidemia and increased atherosclerosis. We applied systems pharmacology to identify and validate specific regulatory gene networks (RGNs) through which ART drugs may...

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發表在:Circ Genom Precis Med
Main Authors: Frades, Itziar, Readhead, Ben, Amadori, Letizia, Koplev, Simon, Talukdar, Husain A., Crane, Heidi M., Crane, Paul K., Kovacic, Jason C., Dudley, Joel T., Giannarelli, Chiara, Björkegren, Johan LM., Peter, Inga
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601350/
https://ncbi.nlm.nih.gov/pubmed/31059280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGEN.118.002390
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