4th international conference on tumor progression and therapeutic resistance: meeting report

od Prabhu, Varun V, El-Deiry, Wafik S
Wydane w Cancer Biol Ther (2015)

CTGF-mediated autophagy-senescence transition in tumor stroma promotes anabolic tumor growth and metastasis

od Prabhu, Varun V., Warfel, Noel A., El-Deiry, Wafik S.
Wydane 2012

Small molecule ONC201/TIC10 targets chemotherapy-resistant colorectal cancer stem-like cells in an Akt/Foxo3a/TRAIL-dependent manner

od Prabhu, Varun V., Allen, Joshua E., Dicker, David T., El-Deiry, Wafik S.
Wydane w Cancer Res (2015)

Therapeutic targeting of the p53 pathway in cancer stem cells

od Prabhu, Varun V., Allen, Joshua E., Hong, Bo, Zhang, Shengliang, Cheng, Hairong, El-Deiry, Wafik S.
Wydane 2012

Prodigiosin rescues deficient p53 signaling and anti-tumor effects via up-regulating p73 and disrupting its interaction with mutant p53

od Hong, Bo, Prabhu, Varun V., Zhang, Shengliang, van den Heuvel, A. Pieter J., Dicker, David T., Kopelovich, Levy, El-Deiry, Wafik S.
Wydane w Cancer Res (2013)

ACTR-51. CLINICAL EVALUATION OF THE IMIPRIDONE ONC201 IN RECURRENT GLIOBLASTOMA: PREDICTIVE AND PHARMACODYNAMIC BIOMARKER ANALYSES

od Arrillaga-Romany, Isabel, Allen, Joshua E, Prabhu, Varun V, Tarapore, Rohinton S, Zloza, Andrew, Oster, Wolfgang, Wen, Patrick Y, Batchelor, Tracy
Wydane w Neuro Oncol (2017)

ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases

od Kline, C. Leah B., Van den Heuvel, A. Pieter J., Allen, Joshua E., Prabhu, Varun V., Dicker, David T., El-Deiry, Wafik S.
Wydane w Sci Signal (2016)

Epidermal growth factor receptor as a molecular determinant of glioblastoma response to dopamine receptor D2 inhibitors

od He, Yuyu, Li, Jie, Koga, Tomoyuki, Ma, Jun, Dhawan, Sanjay, Suzuki, Yuta, Furnari, Frank, Prabhu, Varun V, Allen, Joshua E, Chen, Clark C
Wydane w Neuro Oncol (2020)

Genetic and pharmacological screens converge in identifying FLIP, BCL2 and IAP proteins as key regulators of sensitivity to the TRAIL-inducing anti-cancer agent ONC201/TIC10

od Allen, Joshua E., Prabhu, Varun V., Talekar, Mala, van den Heuvel, AP, Lim, Bora, Dicker, David T., Fritz, Jennifer L., Beck, Adam, El-Deiry, Wafik S.
Wydane w Cancer Res (2015)

ONC201 demonstrates anti-tumor effects in both triple negative and non-triple negative breast cancers through TRAIL-dependent and TRAIL-independent mechanisms

od Ralff, Marie D., Kline, Christina L.B., Küçükkase, Ozan C, Wagner, Jessica, Lim, Bora, Dicker, David T., Prabhu, Varun V., Oster, Wolfgang, El-Deiry, Wafik S.
Wydane w Mol Cancer Ther (2017)

Biological activity of weekly ONC201 in adult recurrent glioblastoma patients

od Arrillaga-Romany, Isabel, Odia, Yazmin, Prabhu, Varun V, Tarapore, Rohinton S, Merdinger, Krystal, Stogniew, Martin, Oster, Wolfgang, Allen, Joshua E, Mehta, Minesh, Batchelor, Tracy T, Wen, Patrick Y
Wydane w Neuro Oncol (2020)

Small molecule NSC59984 restores p53 pathway signaling and anti-tumor effects against colorectal cancer via p73 activation and degradation of mutant p53

od Zhang, Shengliang, Zhou, Lanlan, Hong, Bo, van den Heuvel, A. Pieter J., Prabhu, Varun V., Warfel, Noel A., Kline, Christina Leah B., Dicker, David T., Kopelovich, Levy, El-Deiry, Wafik S.
Wydane w Cancer Res (2015)

Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP

od Lev, Avital, Lulla, Amriti R., Wagner, Jessica, Ralff, Marie D., Kiehl, Joshua B., Zhou, Yan, Benes, Cyril H., Prabhu, Varun V., Oster, Wolfgang, Astsaturov, Igor, Dicker, David T., El-Deiry, Wafik S.
Wydane w Oncotarget (2017)

ONC201 demonstrates anti-tumorigenic and anti-metastatic activity in uterine serous carcinoma in vitro

od Fang, Ziwei, Wang, Jiandong, Clark, Leslie H, Sun, Wenchuan, Yin, Yajie, Kong, Weimin, Pierce, Stuart R, West, Lindsay, Sullivan, Stephanie A, Tran, Arthur-Quan, Prabhu, Varun V, Zhou, Chunxiao, Bae-Jump, Victoria
Wydane w Am J Cancer Res (2018)

Metabolic Reprogramming by Dual AKT/ERK Inhibition Through Imipridones Elicits Unique Vulnerabilities in Glioblastoma

od Ishida, Chiaki T., Zhang, Yiru, Bianchetti, Elena, Shu, Chang, Trang, Nguyen T. T., Kleiner, Giulio, Sanchez-Quintero, Maria J., Quinzii, Catarina M., Westhoff, Mike-Andrew, Karpel-Massler, Georg, Prabhu, Varun V., Allen, Joshua E., Siegelin, Markus D.
Wydane w Clin Cancer Res (2018)

Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212

od Wagner, Jessica, Kline, Christina Leah, Ralff, Marie D., Lev, Avital, Lulla, Amriti, Zhou, Lanlan, Olson, Gary L., Nallaganchu, Bhaskara Rao, Benes, Cyril H., Allen, Joshua E., Prabhu, Varun V., Stogniew, Martin, Oster, Wolfgang, El-Deiry, Wafik S.
Wydane w Cell Cycle (2017)

Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia

od Nii, Takenobu, Prabhu, Varun V., Ruvolo, Vivian, Madhukar, Neel, Zhao, Ran, Mu, Hong, Heese, Lauren, Nishida, Yuki, Kojima, Kensuke, Garnett, Mathew J., McDermott, Ultan, Benes, Cyril H., Charter, Neil, Deacon, Sean, Elemento, Olivier, Allen, Joshua E., Oster, Wolfgang, Stogniew, Martin, Ishizawa, Jo, Andreeff, Michael
Wydane w Leukemia (2019)

Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors

od Prabhu, Varun V., Lulla, Amriti R., Madhukar, Neel S., Ralff, Marie D., Zhao, Dan, Kline, Christina Leah B., Van den Heuvel, A. Pieter J., Lev, Avital, Garnett, Mathew J., McDermott, Ultan, Benes, Cyril H., Batchelor, Tracy T., Chi, Andrew S., Elemento, Olivier, Allen, Joshua E., El-Deiry, Wafik S.
Wydane w PLoS One (2017)

Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies

od Prabhu, Varun V., Talekar, Mala K., Lulla, Amriti R., Kline, C. Leah B., Zhou, Lanlan, Hall, Junior, Van den Heuvel, A. Pieter J., Dicker, David T., Babar, Jawad, Grupp, Stephan A., Garnett, Mathew J., McDermott, Ultan, Benes, Cyril H., Pu, Jeffrey J., Claxton, David F., Khan, Nadia, Oster, Wolfgang, Allen, Joshua E., El-Deiry, Wafik S.
Wydane w Cell Cycle (2018)

Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism

od Prabhu, Varun V., Madhukar, Neel S., Gilvary, Coryandar, Kline, C. Leah B., Oster, Sophie, El-Deiry, Wafik S., Elemento, Olivier, Doherty, Faye, VanEngelenburg, Alexander, Durrant, Jessica, Tarapore, Rohinton S., Deacon, Sean, Charter, Neil, Jung, Jinkyu, Park, Deric M., Gilbert, Mark R., Rusert, Jessica, Wechsler-Reya, Robert, Arrillaga-Romany, Isabel, Batchelor, Tracy T., Wen, Patrick Y., Oster, Wolfgang, Allen, Joshua E.
Wydane w Clin Cancer Res (2018)