Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors

Cancer stem cells (CSCs) correlate with recurrence, metastasis and poor survival in clinical studies. Encouraging results from clinical trials of CSC inhibitors have further validated CSCs as therapeutic targets. ONC201 is a first-in-class small molecule imipridone in Phase I/II clinical trials for...

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Veröffentlicht in:PLoS One
Hauptverfasser: Prabhu, Varun V., Lulla, Amriti R., Madhukar, Neel S., Ralff, Marie D., Zhao, Dan, Kline, Christina Leah B., Van den Heuvel, A. Pieter J., Lev, Avital, Garnett, Mathew J., McDermott, Ultan, Benes, Cyril H., Batchelor, Tracy T., Chi, Andrew S., Elemento, Olivier, Allen, Joshua E., El-Deiry, Wafik S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540272/
https://ncbi.nlm.nih.gov/pubmed/28767654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180541
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