Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors

Cancer stem cells (CSCs) correlate with recurrence, metastasis and poor survival in clinical studies. Encouraging results from clinical trials of CSC inhibitors have further validated CSCs as therapeutic targets. ONC201 is a first-in-class small molecule imipridone in Phase I/II clinical trials for...

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Vydáno v:PLoS One
Hlavní autoři: Prabhu, Varun V., Lulla, Amriti R., Madhukar, Neel S., Ralff, Marie D., Zhao, Dan, Kline, Christina Leah B., Van den Heuvel, A. Pieter J., Lev, Avital, Garnett, Mathew J., McDermott, Ultan, Benes, Cyril H., Batchelor, Tracy T., Chi, Andrew S., Elemento, Olivier, Allen, Joshua E., El-Deiry, Wafik S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540272/
https://ncbi.nlm.nih.gov/pubmed/28767654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180541
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