Genetic and pharmacological screens converge in identifying FLIP, BCL2 and IAP proteins as key regulators of sensitivity to the TRAIL-inducing anti-cancer agent ONC201/TIC10

ONC201/TIC10 is a small molecule inducer of the TRAIL gene under current investigation as a novel anticancer agent. In this study, we identify critical molecular determinants of ONC201 sensitivity offering potential utility as pharmacodynamic or predictive response markers. By screening a library of...

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Bibliografische gegevens
Gepubliceerd in:Cancer Res
Hoofdauteurs: Allen, Joshua E., Prabhu, Varun V., Talekar, Mala, van den Heuvel, AP, Lim, Bora, Dicker, David T., Fritz, Jennifer L., Beck, Adam, El-Deiry, Wafik S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4541796/
https://ncbi.nlm.nih.gov/pubmed/25681273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2356
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