Biological activity of weekly ONC201 in adult recurrent glioblastoma patients

BACKGROUND: ONC201 is a dopamine receptor D2 (DRD2) antagonist that penetrates the blood–brain barrier. ONC201 efficacy has been shown in glioblastoma animal models and is inversely correlated with dopamine receptor DRD5 expression. ONC201 is well tolerated in adult recurrent glioblastoma patients w...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Arrillaga-Romany, Isabel, Odia, Yazmin, Prabhu, Varun V, Tarapore, Rohinton S, Merdinger, Krystal, Stogniew, Martin, Oster, Wolfgang, Allen, Joshua E, Mehta, Minesh, Batchelor, Tracy T, Wen, Patrick Y
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Clinical Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7080220/
https://ncbi.nlm.nih.gov/pubmed/31702782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz164
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