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Biological activity of weekly ONC201 in adult recurrent glioblastoma patients
BACKGROUND: ONC201 is a dopamine receptor D2 (DRD2) antagonist that penetrates the blood–brain barrier. ONC201 efficacy has been shown in glioblastoma animal models and is inversely correlated with dopamine receptor DRD5 expression. ONC201 is well tolerated in adult recurrent glioblastoma patients w...
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| Publié dans: | Neuro Oncol |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7080220/ https://ncbi.nlm.nih.gov/pubmed/31702782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz164 |
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