Biological activity of weekly ONC201 in adult recurrent glioblastoma patients

BACKGROUND: ONC201 is a dopamine receptor D2 (DRD2) antagonist that penetrates the blood–brain barrier. ONC201 efficacy has been shown in glioblastoma animal models and is inversely correlated with dopamine receptor DRD5 expression. ONC201 is well tolerated in adult recurrent glioblastoma patients w...

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Enregistré dans:
Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Arrillaga-Romany, Isabel, Odia, Yazmin, Prabhu, Varun V, Tarapore, Rohinton S, Merdinger, Krystal, Stogniew, Martin, Oster, Wolfgang, Allen, Joshua E, Mehta, Minesh, Batchelor, Tracy T, Wen, Patrick Y
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Clinical Investigations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7080220/
https://ncbi.nlm.nih.gov/pubmed/31702782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz164
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