ACTR-33. TUMOR TISSUE PENETRATION AND PHARMACODYNAMICS OF ONC201 IN ADULT RECURRENT GLIOBLASTOMA PATIENTS

BACKGROUND: ONC201 selectively antagonizes DRD2, crosses the blood-brain barrier and induces apoptosis in high grade gliomas and other advanced cancers. ONC201 efficacy is pronounced in glioma cells that harbor low DRD5 expression and is associated with induction of the ATF4/CHOP/DR5-mediated integr...

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Xehetasun bibliografikoak
Argitaratua izan da:Neuro Oncol
Egile Nagusiak: Arrillaga-Romany, Isabel, Odia, Yazmin, Allen, Joshua, Prabhu, Varun Vijay, Tarapore, Rohinton, Costa, Debora Vendramini, Shah, Neelima, Cukierman, Edna, Oster, Wolfgang, Mehta, Minesh, Wen, Patrick, Batchelor, Tracy
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2018
Gaiak:
Abstracts
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216185/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.066
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