ACTR-33. TUMOR TISSUE PENETRATION AND PHARMACODYNAMICS OF ONC201 IN ADULT RECURRENT GLIOBLASTOMA PATIENTS

BACKGROUND: ONC201 selectively antagonizes DRD2, crosses the blood-brain barrier and induces apoptosis in high grade gliomas and other advanced cancers. ONC201 efficacy is pronounced in glioma cells that harbor low DRD5 expression and is associated with induction of the ATF4/CHOP/DR5-mediated integr...

詳細記述

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書誌詳細
出版年:Neuro Oncol
主要な著者: Arrillaga-Romany, Isabel, Odia, Yazmin, Allen, Joshua, Prabhu, Varun Vijay, Tarapore, Rohinton, Costa, Debora Vendramini, Shah, Neelima, Cukierman, Edna, Oster, Wolfgang, Mehta, Minesh, Wen, Patrick, Batchelor, Tracy
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2018
主題:
Abstracts
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216185/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.066
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