ACTR-33. TUMOR TISSUE PENETRATION AND PHARMACODYNAMICS OF ONC201 IN ADULT RECURRENT GLIOBLASTOMA PATIENTS

BACKGROUND: ONC201 selectively antagonizes DRD2, crosses the blood-brain barrier and induces apoptosis in high grade gliomas and other advanced cancers. ONC201 efficacy is pronounced in glioma cells that harbor low DRD5 expression and is associated with induction of the ATF4/CHOP/DR5-mediated integr...

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Pubblicato in:Neuro Oncol
Autori principali: Arrillaga-Romany, Isabel, Odia, Yazmin, Allen, Joshua, Prabhu, Varun Vijay, Tarapore, Rohinton, Costa, Debora Vendramini, Shah, Neelima, Cukierman, Edna, Oster, Wolfgang, Mehta, Minesh, Wen, Patrick, Batchelor, Tracy
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
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Abstracts
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216185/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.066
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