ACTR-33. TUMOR TISSUE PENETRATION AND PHARMACODYNAMICS OF ONC201 IN ADULT RECURRENT GLIOBLASTOMA PATIENTS

BACKGROUND: ONC201 selectively antagonizes DRD2, crosses the blood-brain barrier and induces apoptosis in high grade gliomas and other advanced cancers. ONC201 efficacy is pronounced in glioma cells that harbor low DRD5 expression and is associated with induction of the ATF4/CHOP/DR5-mediated integr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuro Oncol
Prif Awduron: Arrillaga-Romany, Isabel, Odia, Yazmin, Allen, Joshua, Prabhu, Varun Vijay, Tarapore, Rohinton, Costa, Debora Vendramini, Shah, Neelima, Cukierman, Edna, Oster, Wolfgang, Mehta, Minesh, Wen, Patrick, Batchelor, Tracy
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2018
Pynciau:
Abstracts
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216185/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.066
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