26- and 27-Methyl groups of 2-substituted, 19-nor-1α,25-dihydroxylated vitamin D compounds are essential for calcium mobilization in vivo

Por Grzywacz, Pawel, Plum, Lori A., Clagett-Dame, Margaret, DeLuca, Hector F.
Publicado em 2013

Ring-A-seco analogs of α,25-dihydroxy-19-norvitamin D(3)

Por Glebocka, Agnieszka, Sicinski, Rafal R., Plum, Lori A., DeLuca, Hector F.
Publicado em 2012

Salate derivatives found in sunscreens block experimental autoimmune encephalomyelitis in mice

Por Wang, Yanping, Marling, Steven J., Plum, Lori A., DeLuca, Hector F.
Publicado no Proc Natl Acad Sci U S A (2017)

Suppression of experimental autoimmune encephalomyelitis by ultraviolet light is not mediated by isomerization of urocanic acid

Por Irving, Amy A., Marling, Steven J., Plum, Lori A., DeLuca, Hector F.
Publicado no BMC Neurosci (2017)

Vitamin D deficiency in the Apc(Pirc/+) rat does not exacerbate colonic tumorigenesis, while low dietary calcium might be protective

Por Irving, Amy A., Duchow, Elizabeth G., Plum, Lori A., DeLuca, Hector F.
Publicado no Dis Model Mech (2018)

Removal of the 26-methyl group from 19-nor-1α,25-dihydroxyvitamin D(3) markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation...

Por Grzywacz, Pawel, Chiellini, Grazia, Plum, Lori A., Clagett-Dame, Margaret, DeLuca, Hector F.
Publicado em 2010

26-Desmethyl-2-methylene-22-ene-19-nor-1α,25-dihydroxyvitamin D(3) compounds selectively active on intestine

Por Chiellini, Grazia, Grzywacz, Pawel, Plum, Lori A., Clagett-Dame, Margaret, DeLuca, Hector F.
Publicado no Steroids (2014)

A Methylene Group on C-2 of 24,24-Difluoro-19-nor-1α,25-Dihydroxyvitamin D(3) Markedly Increases Bone Calcium Mobilization in vivo

Por Flores, Agnieszka, Massarelli, Ilaria, Thoden, James B., Plum, Lori A., DeLuca, Hector F.
Publicado no J Med Chem (2015)

Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1α-hydroxyvitamin D(3)-26,23-lactones—weak agonists

Por Chiellini, Grazia, Grzywacz, Pawel, Plum, Lori A., Barycki, Rafal, Clagett-Dame, Margaret, DeLuca, Hector. F.
Publicado no Bioorg Med Chem (2008)

Removal of the 20-methyl group from 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D(3) (2MD) selectively eliminates bone calcium mobilization activity

Por Barycki, Rafal, Sicinski, Rafal R., Plum, Lori A., Grzywacz, Pawel, Clagett-Dame, Margaret, DeLuca, Hector F.
Publicado em 2009

A potent analog of 1α,25-dihydroxyvitamin D(3) selectively induces bone formation

Por Shevde, Nirupama K., Plum, Lori A., Clagett-Dame, Margaret, Yamamoto, Hironori, Pike, J. Wesley, DeLuca, Hector F.
Publicado em 2002

Biologically active noncalcemic analogs of 1α,25-dihydroxyvitamin D with an abbreviated side chain containing no hydroxyl

Por Plum, Lori A., Prahl, Jean M., Ma, Xiaohong, Sicinski, Rafal R., Gowlugari, Sumithra, Clagett-Dame, Margaret, DeLuca, Hector F.
Publicado em 2004

A 20S Combined with a 22R Configuration Markedly Increases both in vivo and in vitro Biological Activity of 1α,25-Dihydroxy-22-methyl-2-methylene-19-norvitamin D(3)

Por Flores, Agnieszka, Sicinski, Rafal R., Grzywacz, Pawel, Thoden, James B., Plum, Lori A., Clagett-Dame, Margaret, DeLuca, Hector F.
Publicado em 2012

1,25-Dihydroxyvitamin D(3) Controls a Cohort of Vitamin D Receptor Target Genes in the Proximal Intestine That Is Enriched for Calcium-regulating Components

Por Lee, Seong Min, Riley, Erin M., Meyer, Mark B., Benkusky, Nancy A., Plum, Lori A., DeLuca, Hector F., Pike, J. Wesley
Publicado no J Biol Chem (2015)

Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase

Por Chiellini, Grazia, Rapposelli, Simona, Zhu, Jinge, Massarelli, Ilaria, Saraceno, Marilena, Bianucci, Anna Maria, Plum, Lori A., Clagett-Dame, Margaret, DeLuca, Hector F.
Publicado em 2011

Cholecalciferol or 25-Hydroxycholecalciferol Neither Prevents Nor Treats Adenomas in a Rat Model of Familial Colon Cancer(1)(2)

Por Irving, Amy A, Plum, Lori A, Blaser, William J, Ford, Madeline R, Weng, Chao, Clipson, Linda, DeLuca, Hector F, Dove, William F
Publicado no J Nutr (2015)

Pharmacokinetics of a New Oral Vitamin D Receptor Activator (2-Methylene-19-Nor-(20S)-1α,25-Dihydroxyvitamin D(3)) in Patients with Chronic Kidney Disease and Secondary Hyperparath...

Por Pandey, Richa, Zella, Julia B., Zhu, Jinge G., Plum, Lori A., Clagett-Dame, Margaret, Blaser, William J., Bedale, Wendy, DeLuca, Hector F., Coyne, Daniel W.
Publicado no Drugs R D (2017)

Supplementation by vitamin D compounds does not affect colonic tumor development in vitamin D sufficient murine models

Por Irving, Amy A., Halberg, Richard B., Albrecht, Dawn M., Plum, Lori A., Krentz, Kathleen J., Clipson, Linda, Drinkwater, Norman, Amos-Landgraf, James M., Dove, William F., DeLuca, Hector F.
Publicado em 2011