A Methylene Group on C-2 of 24,24-Difluoro-19-nor-1α,25-Dihydroxyvitamin D(3) Markedly Increases Bone Calcium Mobilization in vivo

Four side chain fluorinated analogues of 1α,25-dihydroxy-19-norvitamin D have been prepared in convergent syntheses using the Wittig-Horner reaction as a key step. Structures and absolute configurations of analogues 3 and 5 were confirmed by X-ray crystallography. All analogues showed high potency i...

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Publicado en:J Med Chem
Main Authors: Flores, Agnieszka, Massarelli, Ilaria, Thoden, James B., Plum, Lori A., DeLuca, Hector F.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4698824/
https://ncbi.nlm.nih.gov/pubmed/26630444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01564
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