Removal of the 20-methyl group from 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D(3) (2MD) selectively eliminates bone calcium mobilization activity

Eitemau Tebyg

• 26-Desmethyl-2-methylene-22-ene-19-nor-1α,25-dihydroxyvitamin D(3) compounds selectively active on intestine
  gan: Chiellini, Grazia, et al.
  Cyhoeddwyd: (2014)
• Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1α-hydroxyvitamin D(3)-26,23-lactones—weak agonists
  gan: Chiellini, Grazia, et al.
  Cyhoeddwyd: (2008)
• A 20S Combined with a 22R Configuration Markedly Increases both in vivo and in vitro Biological Activity of 1α,25-Dihydroxy-22-methyl-2-methylene-19-norvitamin D(3)
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  Cyhoeddwyd: (2012)
• 26- and 27-Methyl groups of 2-substituted, 19-nor-1α,25-dihydroxylated vitamin D compounds are essential for calcium mobilization in vivo
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  Cyhoeddwyd: (2013)
• Removal of the 26-methyl group from 19-nor-1α,25-dihydroxyvitamin D(3) markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation and transcription
  gan: Grzywacz, Pawel, et al.
  Cyhoeddwyd: (2010)