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26- and 27-Methyl groups of 2-substituted, 19-nor-1α,25-dihydroxylated vitamin D compounds are essential for calcium mobilization in vivo
Twelve new analogues of 19-nor-1α,25-dihydroxyvitamin D(3) 6–17, were prepared by a multi-step procedure from known alcohols 18 and 19. We have examined the influence of removing two methyl groups located at C-25, as well as the 25-hydroxy group, on the biological in vitro and in vivo biological act...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3612139/ https://ncbi.nlm.nih.gov/pubmed/23474215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2013.01.001 |
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