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Removal of the 26-methyl group from 19-nor-1α,25-dihydroxyvitamin D(3) markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation and transcription
Twelve new analogs of 19-nor-1α,25-dihydroxyvitamin D(3) (5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 and 16), were prepared by convergent syntheses, employing the Wittig-Horner reaction. The necessary Grundmann-type ketones (45, 46, 47 and 48), possessing fixed configurations of the hydroxyl group at C-2...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3079430/ https://ncbi.nlm.nih.gov/pubmed/21105677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1010447 |
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