Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1α-hydroxyvitamin D(3)-26,23-lactones—weak agonists

In a continuing effort to explore the 2-methylene-1α-hydroxy-19-norvitamin D3 class of pharmacologically important vitamin D compounds, two novel 2-methylene-19-nor-25-dehydro-1α-hydroxyvitamin D(3)-26,23-lactones, GC-3 and HLV, were synthesized and biologically tested. Based on reports of similarly...

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Bibliografiska uppgifter
I publikationen:Bioorg Med Chem
Huvudupphovsmän: Chiellini, Grazia, Grzywacz, Pawel, Plum, Lori A., Barycki, Rafal, Clagett-Dame, Margaret, DeLuca, Hector. F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601569/
https://ncbi.nlm.nih.gov/pubmed/18722130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.08.011
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