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A 20S Combined with a 22R Configuration Markedly Increases both in vivo and in vitro Biological Activity of 1α,25-Dihydroxy-22-methyl-2-methylene-19-norvitamin D(3)
Six new analogues of 1α,25-dihydroxy-19-norvitamin D(3) (3a-4b, 5 and 6) were prepared by a convergent synthesis applying the Wittig-Horner reaction as a key step. The influence of methyl groups at C-22 on their biological activity was examined. It was established that both in vitro and in vivo acti...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3381458/ https://ncbi.nlm.nih.gov/pubmed/22490010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300187x |
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