Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase

Selective inhibitors of CYP24A1 represent an important synthetic target in a search for novel vitamin D compounds of therapeutic value. In the present work, we show the synthesis and biological properties of two novel side chain modified 2-methylene-19-nor-1,25(OH)(2)D(3) analogs, the 22-imidazole-1...

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Detalhes bibliográficos
Main Authors: Chiellini, Grazia, Rapposelli, Simona, Zhu, Jinge, Massarelli, Ilaria, Saraceno, Marilena, Bianucci, Anna Maria, Plum, Lori A., Clagett-Dame, Margaret, DeLuca, Hector F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539163/
https://ncbi.nlm.nih.gov/pubmed/22133546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2011.11.007
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