Head and neck cancer organoids established by modification of the CTOS method can be used to predict in vivo drug sensitivity

le Tanaka, Noriaki, Osman, Abdullah A., Takahashi, Yoko, Lindemann, Antje, Patel, Ameeta A., Zhao, Mei, Takahashi, Hideaki, Myers, Jeffrey N.
Foilsithe in Oral Oncol (2018)

Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cells by targeting the transcription factors FOXO3a and FOXM1

le Tanaka, Noriaki, Zhao, Mei, Tang, Lin, Patel, Ameeta A., Xi, Qing, Van, Hieu T., Takahashi, Hideaki, Osman, Abdullah A., Zhang, Jiexin, Wang, Jing, Myers, Jeffrey N., Zhou, Ge
Foilsithe in Oncogene (2017)

Disruption of TP63-miR-27a* Feedback Loop by Mutant TP53 in Head and Neck Cancer

le Chari, Nikhil S, Ivan, Cristina, Le, Xiandong, Li, Jinzhong, Mijiti, Ainiwaer, Patel, Ameeta A, Osman, Abdullah A, Peterson, Christine B, Williams, Michelle D, Pickering, Curtis R, Caulin, Carlos, Myers, Jeffrey N, Calin, George A, Lai, Stephen Y
Foilsithe in J Natl Cancer Inst (2019)

Combined inhibition of Rad51 and Wee1 enhances cell killing in HNSCC through induction of apoptosis associated with excessive DNA damage and replication stress

le Lindemann, Antje, Patel, Ameeta A., Tang, Lin, Tanaka, Noriaki, Gleber-Netto, Frederico O., Bartels, Mason D., Wang, Li, McGrail, Daniel J, Lin, Shiaw-Yih, Frank, Steven J., Frederick, Mitchell J., Myers, Jeffrey N., Osman, Abdullah A.
Foilsithe in Mol Cancer Ther (2021)

Wee-1 kinase inhibition sensitizes high risk HPV+ HNSCC to apoptosis accompanied by downregulation of MCl-1 and XIAP antiapoptotic proteins

le Tanaka, Noriaki, Patel, Ameeta A., Wang, Jiping, Frederick, Mitchell J., Kalu, Nene N., Zhao, Mei, Fitzgerald, Alison L., Xie, Tong-xin, Silver, Natalie L., Caulin, Carlos, Zhou, Ge, Skinner, Heath D., Johnson, Faye M., Myers, Jeffrey N., Osman, Abdullah A.
Foilsithe in Clin Cancer Res (2015)

Wee-1 Kinase Inhibition Overcomes Cisplatin Resistance Associated with High-Risk TP53 Mutations in Head and Neck Cancer through Mitotic Arrest Followed by Senescence

le Osman, Abdullah A., Monroe, Marcus M., Ortega Alves, Marcus V., Patel, Ameeta A., Katsonis, Panagiotis, Fitzgerald, Alison L., Neskey, David M., Frederick, Mitchell J., Woo, Sang Hyeok, Caulin, Carlos, Hsu, Teng-Kuei, McDonald, Thomas O., Kimmel, Marek, Meyn, Raymond E., Lichtarge, Olivier, Myers, Jeffrey N.
Foilsithe in Mol Cancer Ther (2014)

COTI-2, a novel thiosemicarbazone derivative, exhibits antitumor activity in HNSCC through p53-dependent and -independent mechanisms

le Lindemann, Antje, Patel, Ameeta A., Silver, Natalie L., Tang, Lin, Liu, Zhiyi, Wang, Li, Tanaka, Noriaki, Rao, Xiayu, Takahashi, Hideaki, Maduka, Nakachi K, Zhao, Mei, Chen, Tseng-Cheng, Liu, WeiWei, Gao, Meng, Wang, Jing, Frank, Steven J., Hittelman, Walter N., Mills, Gordon B., Myers, Jeffrey N., Osman, Abdullah A.
Foilsithe in Clin Cancer Res (2019)

Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation

le Zhou, Ge, Wang, Jiping, Zhao, Mei, Xie, Tong-Xin, Tanaka, Noriaki, Sano, Daisuke, Patel, Ameeta A., Ward, Alexandra M, Sandulache, Vlad, Jasser, Samar A., Skinner, Heath D., Fitzgerald, Alison Lea, Osman, Abdullah A., Wei, Yongkun, Xia, Xuefeng, Songyang, Zhou, Mills, Gordon B., Hung, Mien-Chie, Caulin, Carlos, Liang, Jiyong, Myers, Jeffrey N.
Foilsithe 2014

Replication stress leading to apoptosis within the S-phase contributes to synergism between vorinostat and AZD1775 in HNSCC harboring high risk TP53 mutation

le Tanaka, Noriaki, Patel, Ameeta A., Tang, Lin, Silver, Natalie L., Lindemann, Antje, Takahashi, Hideaki, Jaksik, Roman, Rao, Xiayu, Kalu, Nene N., Chen, Tseng-Cheng, Wang, Jiping, Frederick, Mitchell J., Johnson, Faye, Gleber-Netto, Frederico O., Fu, Siqing, Kimmel, Marek, Wang, Jing, Hittelman, Walter N., Pickering, Curtis R., Myers, Jeffrey N., Osman, Abdullah A.
Foilsithe in Clin Cancer Res (2017)

Evolutionary Action Score of TP53 Coding Variants (EAp53) is Predictive of Platinum Response in Head and Neck Cancer Patients

le Osman, Abdullah A., Neskey, David M., Katsonis, Panagiotis, Patel, Ameeta A., Ward, Alexandra M., Hsu, Teng-Kuei, Hicks, Stephanie C., McDonald, Thomas O., Ow, Thomas J., Alves, Marcus Ortega, Pickering, Curtis R., Skinner, Heath D., Zhao, Mei, Sturgis, Eric M., Kies, Merrill S., El-Naggar, Adel, Perrone, Federica, Licitra, Lisa, Bossi, Paolo, Kimmel, Marek, Frederick, Mitchell J., Lichtarge, Olivier, Myers, Jeffrey N.
Foilsithe in Cancer Res (2015)