Replication stress leading to apoptosis within the S-phase contributes to synergism between vorinostat and AZD1775 in HNSCC harboring high risk TP53 mutation

PURPOSE: The cure rate for patients with advanced head and neck squamous cell carcinoma (HNSCC) remains poor due to resistance to standard therapy primarily consisting of chemoradiation. Since mutation of TP53 in HNSCC occurs in 60-80% of non-HPV associated cases and is in turn associated with resis...

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Udgivet i:Clin Cancer Res
Main Authors: Tanaka, Noriaki, Patel, Ameeta A., Tang, Lin, Silver, Natalie L., Lindemann, Antje, Takahashi, Hideaki, Jaksik, Roman, Rao, Xiayu, Kalu, Nene N., Chen, Tseng-Cheng, Wang, Jiping, Frederick, Mitchell J., Johnson, Faye, Gleber-Netto, Frederico O., Fu, Siqing, Kimmel, Marek, Wang, Jing, Hittelman, Walter N., Pickering, Curtis R., Myers, Jeffrey N., Osman, Abdullah A.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724758/
https://ncbi.nlm.nih.gov/pubmed/28790110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0947
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