Wee-1 kinase inhibition sensitizes high risk HPV+ HNSCC to apoptosis accompanied by downregulation of MCl-1 and XIAP antiapoptotic proteins

PURPOSE: Although the majority of patients with HPV+ oropharyngeal cancers have a favorable prognosis, there are some patients with tumors that are resistant to aggressive chemoradiotherapy with unusual patterns of locoregional and systemic recurrence. Therefore, more effective therapies are needed....

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Publicat a:Clin Cancer Res
Autors principals: Tanaka, Noriaki, Patel, Ameeta A., Wang, Jiping, Frederick, Mitchell J., Kalu, Nene N., Zhao, Mei, Fitzgerald, Alison L., Xie, Tong-xin, Silver, Natalie L., Caulin, Carlos, Zhou, Ge, Skinner, Heath D., Johnson, Faye M., Myers, Jeffrey N., Osman, Abdullah A.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631620/
https://ncbi.nlm.nih.gov/pubmed/26124202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0279
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