FOXM1 drives HPV+ HNSCC sensitivity to WEE1 inhibition

Head and neck squamous cell carcinoma (HNSCC) associated with high-risk human papilloma virus (HPV) infection is a growing clinical problem. The WEE1 kinase inhibitor AZD1775 (WEE1i) overrides cell cycle checkpoints and is being studied in HNSCC regimens. We show that the HPV16 E6/E7 oncoproteins se...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Diab, Ahmed, Gem, Hakan, Swanger, Jherek, Kim, Hee Yeon, Smith, Kaleb, Zou, Grace, Raju, Sharat, Kao, Michael, Fitzgibbon, Matthew, Loeb, Keith R., Rodriguez, Cristina P., Méndez, Eduardo, Galloway, Denise A., Sidorova, Julia M., Clurman, Bruce E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7668037/
https://ncbi.nlm.nih.gov/pubmed/33093209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2013921117
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