Requirement for antiapoptotic MCL-1 during early erythropoiesis

Although BCL-xL is critical to the survival of mature erythrocytes, it is still unclear whether other antiapoptotic molecules mediate survival during earlier stages of erythropoiesis. Here, we demonstrate that erythroid-specific Mcl1 deletion results in embryonic lethality beyond embryonic day 13.5...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Turnis, Meghan E., Kaminska, Ewa, Smith, Kaitlyn H., Kartchner, Brittany J., Vogel, Peter, Laxton, Jonathan D., Ashmun, Richard A., Ney, Paul A., Opferman, Joseph T.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2021
Matèries:
Red Cells, Iron, and Erythropoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8033457/
https://ncbi.nlm.nih.gov/pubmed/33512417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020006916
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