COTI-2, a novel thiosemicarbazone derivative, exhibits antitumor activity in HNSCC through p53-dependent and -independent mechanisms

PURPOSE: TP53 mutations are highly prevalent in head and neck squamous cell carcinoma (HNSCC) and associated with increased resistance to conventional treatment primarily consisting of chemotherapy and radiation. Restoration of wildtype p53 function in TP53 mutant cancer cells represents an attracti...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Clin Cancer Res
Egile Nagusiak: Lindemann, Antje, Patel, Ameeta A., Silver, Natalie L., Tang, Lin, Liu, Zhiyi, Wang, Li, Tanaka, Noriaki, Rao, Xiayu, Takahashi, Hideaki, Maduka, Nakachi K, Zhao, Mei, Chen, Tseng-Cheng, Liu, WeiWei, Gao, Meng, Wang, Jing, Frank, Steven J., Hittelman, Walter N., Mills, Gordon B., Myers, Jeffrey N., Osman, Abdullah A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6759991/
https://ncbi.nlm.nih.gov/pubmed/31308060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0096
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